Constitutional growth delay inheritance pattern.Pubertal growth and final height in hypopituitary boys: a minor role of bone age at onset of puberty.Short-term testosterone treatment at bone age of 12 to 13 years does not reduce adult height in boys with constitutional delay of growth and adolescence.Treatment of tall stature in boys: comparison of two different treatment regimens.Short-term, high-dose testosterone treatment fails to reduce adult height in boys with constitutional tall stature.Long term treatment with low dose testosterone in constitutional delay of growth and puberty: effect on bone age maturation and pubertal progression.Testosterone treatment in adolescent boys with constitutional delay of growth and development.A double blind, placebo controlled study of the effects of low dose testosterone undecanoate on the growth of small for age, prepubertal boys.Androgen therapy in constitutional delay of growth.Testosterone treatment in adolescent boys with constitutional delay in growth and development.Final height outcome and value of height prediction in boys with constitutional delay in growth and adolescence treated with intramuscular testosterone 125 mg per month for 3 months.
The data caution against drawing conclusions based on changes observed during androgen therapy in the absence of extended follow-up. Testosterone enanthate 50 mg/mo did not affect predicted adult height adversely, but to the contrary, permitted it to be fully realised. The present study confirms that large doses of androgens compromise adult height and are contraindicated in the treatment of constitutional delay in growth and development. In contrast the control group and those treated with smaller doses of testosterone achieved their predicted heights.
However, the year following treatment, growth velocities reversed so that those who received the largest steroid dose and had grown the fastest, decelerated the most and eventually ended up significantly shorter than their predicted adult height. Nor was there a significant difference in the height prediction by the RWT method before and at the end of treatment. Bone age advanced commensurate with height age in all the treated groups and delta height age/delta bone age ratios at the end of therapy did not differ significantly. All treated subjects achieved an excellent growth response with growth velocities reflecting androgen dose. The 4 groups were similar in chronological age, height, height age, bone age, height age/bone age ratio, pubertal development and had similar predicted adult heights. N2 - The outcome of treatment in 3 groups of boys with constitutional delay in growth and development given monthly intramuscular injections of testosterone enanthate 200 mg (22 subjects) 100 mg (10 subjects) and 50 mg (12 subjects) was compared with the outcome in a control group (14 subjects) without treatment. T1 - Testosterone treatment of constitutional delay in growth and development: effect of dose on predicted versus definitive height.
The outcome of treatment in 3 groups of boys with constitutional delay in growth and development given monthly intramuscular injections of testosterone enanthate 200 mg (22 subjects) 100 mg (10 subjects) and 50 mg (12 subjects) was compared with the outcome in a control group (14 subjects) without treatment.
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